Twitter said it would cut 500 employees, including its chief executive, amid the fallout from its firing of journalist Evan Williams.
The social network said in a statement on Monday that the cuts, which start on Thursday, will result from a change in the nature of its business.
The layoffs, which the company said are part of a wider effort to focus its operations, include about 700 jobs in New York and another 1,000 in London, the statement said.
The company’s chief executive and other senior executives were also laid off.
Twitter did not give details on the specific positions.
Twitter said the changes are designed to better align the company’s core services with its wider product offering.
Twitter said the cuts are not related to the departure of Williams, who left the social network last month to launch his own news network, The Verge.
Twitter previously said he was let go for personal reasons.
Williams’ departure was triggered by a series of controversies involving the social media giant’s hiring practices.
Williams was fired from his job as a news reporter for The New York Times for publishing stories about Twitter’s harassment policy.
His suspension followed allegations that he encouraged users to harass women at the company.
Twitter did not disclose the specific allegations against Williams.
Twitter also said it will provide employees with an email to notify them of any disciplinary action.
It said it is providing an email for employees who have concerns about their personal safety or who have questions regarding their privacy.
It said it also is investigating reports that the company received complaints about a harassment complaint made against a former employee.